Thermo Fisher Scientific Angiotensin I Converting Enzyme (ACE)/CD143 Monoclonal Antibody (ACE, 3765)
인간 ACE/CD143 단백질을 인식하는 마우스 단클론 항체로, Western blot과 파라핀 조직 IHC에 적합합니다. 단백질 A/G로 정제된 액상 항체이며, PBS(pH 7.4)와 0.05% BSA, sodium azide를 포함합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ACE, 3765 |
| Immunogen | Recombinant fragment (around aa 652–788) of human ACE (CD143) protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- IHC (PFA fixed): Incubate antibody for 30 minutes at room temperature.
- For formalin-fixed tissues: Heat tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, then cool at room temperature for 20 minutes.
Target Information
The ACE gene encodes an enzyme that catalyzes the conversion of angiotensin I into angiotensin II, a potent vasopressor and aldosterone-stimulating peptide regulating blood pressure and fluid-electrolyte balance.
This enzyme is a key component of the renin–angiotensin system. Variations in this gene, such as the presence or absence of a 287 bp Alu repeat element, have been linked to circulating enzyme levels and cardiovascular pathophysiology.
Two major alternatively spliced variants encode somatic and testicular isoforms, both enzymatically active. Additional variants exist but their full-length sequences are not fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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