Thermo Fisher Scientific C17orf85 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human C17orf85. Recombinant protein control fragment (Product #RP-89980). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:C17orf85,uniProtId:Q53F19-1,ncbiNodeId:9606,antigenRange:147-256,antigenLength:620,antigenImageFileName:PA5-53033_C17orf85_Q53F19-1_Rabbit.svg,antigenImageFileNamePDP:PA5-53033_C17orf85_Q53F19-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2638840

Product Specific Information

Immunogen sequence: EYPPAHIEWL DDTSCNVVWL DEMTATRALI NMSSLPAQDK IRSRDASEDK SAEKRKKDKQ EDSSDDDEAE EGEVEDENSS DVELDTLSQV EEESLLRNDL RPANKLAKGN

Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.

Target Information

Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.