Thermo Fisher Scientific CD50/ICAM3 Monoclonal Antibody (ICAM3, 1019)
인간 ICAM3 단백질을 인식하는 Mouse IgG2b 단클론 항체로, WB, IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 사용 가능. 고순도 Protein A/G 정제, 4°C 보관 안정성 우수. 면역세포 간 접착 및 활성 연구에 적합.
- 카탈로그번호
- 3385-MSM4-P0
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ICAM3, 1019 |
| Immunogen | Recombinant human ICAM3 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Immunohistochemistry (PFA fixed): Incubate antibody for 30 minutes at room temperature. Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C followed by cooling at room temperature for 20 minutes.
Target Information
CD50 (intracellular adhesion molecule 3, ICAM-3) is a transmembrane glycoprotein expressed by leukocytes and serves as a counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin. It functions as an adhesive molecule mediating contact between T cells and antigen-presenting cells, regulating LFA-1 affinity for ICAM-1, and inducing T cell activation and proliferation. ICAM-3 plays a crucial role in initiating immune responses on both T cells and antigen-presenting cells. It also interacts with CD209 (DC-SIGN), a C-type lectin of dendritic cells and macrophages, facilitating communication between dendritic cells and granulocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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