Thermo Fisher Scientific PKNOX2 Polyclonal Antibody

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence:
  DASNPDPAPKA KKIKSQHRPT QRFWPNSIAA GVLQQQGGAP GTNPDGSINL DNLQSLS
• Highest antigen sequence identity to orthologs:
  Mouse 98%, Rat 98%

Target Information

PREP-2 (Pbx-regulating protein-2), also known as PBX/knotted 1 homeobox 2 or PKNOX2, is a widely expressed protein belonging to the TALE (three amino acid loop extension)/MEIS family. PREP-2 is a DNA-binding protein that forms stable complexes with Pbx proteins. It is highly homologous to the related protein PREP-1 but displays a more restricted tissue distribution and a higher DNA-dissociation rate. Like PREP-1, PREP-2 forms a heterodimer with Pbx1. The PREP-2–Pbx1 dimer relocates to the nucleus where it associates with HoxB1 to form a ternary complex. In contrast with PREP-1, which increases transcriptional activation in this ternary complex, PREP-2 slightly decreases transcriptional activity. Multiple isoforms exist for PREP-2, localizing to the nucleus or cytoplasm. Cytoplasmic isoforms are believed to colocalize with F-actin, G-actin, and tubulin/microtubules.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.