Thermo Fisher Scientific PKNOX2 Polyclonal Antibody
Thermo Fisher Scientific PKNOX2 Polyclonal Antibody는 인간 PKNOX2 단백질을 인식하는 토끼 유래 IgG 항체입니다. ICC/IF에 0.25–2 µg/mL로 사용되며, 항원 친화 크로마토그래피로 정제되었습니다. PBS(glycerol 40%)에 보관하며, 연구용으로만 사용됩니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human PKNOX2. Recombinant protein control fragment (Product #RP-106627). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664428 |
Product Specific Information
- Immunogen sequence:
DASNPDPAPKA KKIKSQHRPT QRFWPNSIAA GVLQQQGGAP GTNPDGSINL DNLQSLS - Highest antigen sequence identity to orthologs:
Mouse 98%, Rat 98%
Target Information
PREP-2 (Pbx-regulating protein-2), also known as PBX/knotted 1 homeobox 2 or PKNOX2, is a widely expressed protein belonging to the TALE (three amino acid loop extension)/MEIS family. PREP-2 is a DNA-binding protein that forms stable complexes with Pbx proteins. It is highly homologous to the related protein PREP-1 but displays a more restricted tissue distribution and a higher DNA-dissociation rate. Like PREP-1, PREP-2 forms a heterodimer with Pbx1. The PREP-2–Pbx1 dimer relocates to the nucleus where it associates with HoxB1 to form a ternary complex. In contrast with PREP-1, which increases transcriptional activation in this ternary complex, PREP-2 slightly decreases transcriptional activity. Multiple isoforms exist for PREP-2, localizing to the nucleus or cytoplasm. Cytoplasmic isoforms are believed to colocalize with F-actin, G-actin, and tubulin/microtubules.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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