Thermo Fisher Scientific PKNOX2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human PKNOX2. Recombinant protein control fragment (Product #RP-106627). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PKNOX2,uniProtId:Q96KN3-1,ncbiNodeId:9606,antigenRange:352-409,antigenLength:472,antigenImageFileName:PA5-65946_PKNOX2_Q96KN3-1_Rabbit.svg,antigenImageFileNamePDP:PA5-65946_PKNOX2_Q96KN3-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2664428

Product Specific Information

Immunogen sequence: DASNPDPAPKA KKIKSQHRPT QRFWPNSIAA GVLQQQGGAP GTNPDGSINL DNLQSLS

Highest antigen sequence identity to the following orthologs - mouse 98%, rat 98%.

Target Information

PREP-2 (Pbx-regulating protein-2), also known as PBX/knotted 1 homeobox 2 or PKNOX2, is a widely expressed protein belonging to the TALE (three amino acid loop extension)/MEIS family. PREP-2 is a DNA-binding protein that forms stable complexes with Pbx proteins. It is highly homologous to the related protein PREP-1, but displays a more restricted tissue distribution and a higher DNA-dissociation rate. Like PREP-1, PREP-2 forms a heterodimer with Pbx 1. The PREP-2-Pbx 1 dimer is relocated to the nucleus where it associates with HoxB1 to form a ternary complex. In contrast with PREP-1, which acts to increase transcriptional activation in this ternary complex, PREP-2 leads to a slight decrease in transcriptional activity of the ternary complex. Multiple isoforms exist for PREP-2, localizing to the nucleus or cytoplasm. Cytoplasmic isoforms are believed to colocalize with F-actin, G-actin and tubulin/microtubules.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.