Thermo Fisher Scientific Arg3.1 Polyclonal Antibody
인간 Arg3.1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, WB, IHC, SPR 등 다양한 연구용 분석에 적합합니다. 액상 형태로 제공되며, 고순도 친화 크로마토그래피로 정제되어 신경가소성과 시냅스 연구에 활용됩니다.
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Thermo Fisher Scientific Arg3.1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–1.0 µg/mL |
| Immunohistochemistry (IHC) | 5.0 µg/mL |
| Surface Plasmon Resonance (SPR) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human Arg3.1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2688621 |
Product Specific Information
This target displays homology in the following species:
Cow: 100%; Goat: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rat: 100%
Target Information
Arg3.1 (ARC) is a master regulator of synaptic plasticity that self-assembles into virion-like capsids encapsulating RNAs for intercellular RNA transfer in the nervous system. ARC protein is released from neurons via extracellular vesicles, mediating ARC mRNA transfer and activity-dependent translation in target cells.
It is essential for long-term potentiation (LTP), long-term depression (LTD), and long-term memory formation. ARC regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity, contributing to neuronal homeostasis through synaptic scaling.
Additionally, ARC acts as a postsynaptic mediator for synapse elimination during cerebellar development and plays a role in amyloid-beta A4 (APP) processing via interaction with PSEN1. Beyond synaptic functions, ARC is expressed in skin-migratory dendritic cells, regulating fast dendritic cell migration and T-cell activation.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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