Thermo Fisher Scientific PD-L2 (PDCD1LG2) Monoclonal Antibody (OTI11F9), TrueMAB
인간 PD-L2 단백질을 인식하는 단일클론 항체로, Western blot 및 유세포분석에 적합. TrueMAB 포맷의 Mouse IgG1 항체로 고순도 친화성 크로마토그래피 정제. PBS/BSA/glycerol 완충액에 보존되며 연구용으로만 사용 가능.
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Thermo Fisher Scientific PD-L2 (PDCD1LG2) Monoclonal Antibody (OTI11F9), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Flow Cytometry (Flow) | Assay-Dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI11F9 |
| Immunogen | Full-length human recombinant PDCD1LG2 protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Programmed death-ligand 2 (PD-L2), also known as B7-DC, is a member of the B7 ligand family within the immunoglobulin superfamily. Along with PD-L1, it serves as a ligand for PD-1, an inhibitory immune checkpoint molecule. PD-L2 is primarily expressed in dendritic cells but can be induced in various cell types depending on the microenvironment. Its expression is upregulated by cytokines such as IL-4, TNF-alpha, and IFN-gamma. PD-L2 binds PD-1 with higher affinity than PD-L1 and plays a role in regulating immune responses by inhibiting T cell activation and cytokine secretion. Additionally, PD-L2 interacts with RGMb, influencing respiratory tolerance through BMP and neogenin signaling pathways. The human PD-L2 monomer comprises a 201-amino-acid extracellular domain, a 21-amino-acid transmembrane domain, and a 32-amino-acid cytoplasmic domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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