Thermo Fisher Scientific PD-L2 (PDCD1LG2) Monoclonal Antibody (OTI11F9), TrueMAB

Thermo Fisher Scientific PD-L2 (PDCD1LG2) Monoclonal Antibody (OTI11F9), TrueMAB

Applications and Tested Dilution

Product Specifications

Target Information

Programmed death-ligand 2 (PD-L2), also known as B7-DC, is a member of the B7 ligand family within the immunoglobulin superfamily. Along with PD-L1, it serves as a ligand for PD-1, an inhibitory immune checkpoint molecule. PD-L2 is primarily expressed in dendritic cells but can be induced in various cell types depending on the microenvironment. Its expression is upregulated by cytokines such as IL-4, TNF-alpha, and IFN-gamma. PD-L2 binds PD-1 with higher affinity than PD-L1 and plays a role in regulating immune responses by inhibiting T cell activation and cytokine secretion. Additionally, PD-L2 interacts with RGMb, influencing respiratory tolerance through BMP and neogenin signaling pathways. The human PD-L2 monomer comprises a 201-amino-acid extracellular domain, a 21-amino-acid transmembrane domain, and a 32-amino-acid cytoplasmic domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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