Thermo Fisher Scientific RNF213 Polyclonal Antibody
Human RNF213 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC(P), ICC/IF에 적용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보존. 혈관 발생 및 비정상적 Wnt 신호 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human RNF213 (Product # RP-102049) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2646661 |
Product Specific Information
Immunogen sequence:
VGKNEQGEPE DLKKPEGKNR SAAAVKNEKE QKNQEADVQE VKASTLSPGG GVTVFFHAII SLHFPFNPDL HKVFIRGGEE FGESKWDSNI CELHYTRDLG HDRVLVEGIV CISKKHLDKY IPYKYVIYNG ESFEYEFIYK H
Antigen sequence identity:
- Mouse: 47%
- Rat: 48%
Target Information
RNF213 is an E3 ubiquitin-protein ligase involved in angiogenesis. It participates in the non-canonical Wnt signaling pathway in vascular development by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, thereby inhibiting the non-canonical Wnt signaling pathway and promoting vessel regression. RNF213 also possesses ATPase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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