Thermo Fisher Scientific ACY1 Monoclonal Antibody (OTI2D3), TrueMAB

Applications and Tested Dilution

Product Specifications

Target Information

ACY1 encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group. It functions in the catabolism and salvage of acylated amino acids.
This gene is located on chromosome 3p21.1, a region often reduced to homozygosity in small-cell lung cancer (SCLC), where its expression is frequently reduced or undetectable.
The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart and represents the first member of a new family of zinc-binding enzymes.
Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder associated with central nervous system defects and increased urinary excretion of N-acetylated amino acids.
Alternative splicing results in multiple transcript variants, and read-through transcription occurs between this gene and the upstream ABHD14A gene. A related pseudogene is located on chromosome 18.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.