Thermo Fisher Scientific proBDNF Polyclonal Antibody
Thermo Fisher Scientific의 proBDNF Polyclonal Antibody는 rat proBDNF 합성 펩타이드로부터 제작된 sheep IgG 항체입니다. Western blot과 IHC에 사용 가능하며, 뇌 유래 신경영양인자(BDNF) 연구에 적합합니다. 동결 건조 형태로 제공되며 4°C 또는 -20°C에서 안정적으로 보관할 수 있습니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:2,000 |
| Immunohistochemistry (IHC) | 1:300–1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from rat proBDNF |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Conditions | Store at 4°C for short term. For long-term storage, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10709429 |
Product Specific Information
- Glycerol (1:1) may be added for additional stability.
- Reconstitute in 100 µL of sterile water.
Target Information
BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family. It is synthesized as pre-proBDNF, then cleaved to proBDNF. Further processing generates the mature 14 kDa protein, but proBDNF itself is biologically active and secreted in synaptic vesicles alongside the mature form.
BDNF is widely expressed in the central nervous system and acts in both autocrine and paracrine manners on various neuron classes. Signaling primarily occurs through the TrkB receptor, though binding to the lower-affinity receptor p75-NTR has also been observed. BDNF promotes neuronal survival, differentiation, memory formation, and synaptic regulation. Its expression is reduced in Alzheimer’s and Huntington’s disease patients and may be involved in stress response and mood disorder regulation.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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