Thermo Fisher Scientific Human TRANCE (RANKL) (soluble), Animal-Free Recombinant Protein, PeproTech
인간 RANKL(TNF 계열) 재조합 단백질로 동물 유래 성분이 없는 고순도(≥98%) 제품입니다. HT-29 NF-κB reporter 세포에서 기능적 활성을 확인하였으며, 골파골세포 분화 및 면역 반응 연구에 적합합니다. E. coli에서 발현된 20 kDa 단백질로 -20°C 보관합니다.
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Applications
Functional Assay (Functional)
- Assay-dependent
In vitro Assay (IV)
- Refer to publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published Species | Human |
| Expression System | E. coli |
| Amino Acid Sequence | MEKAMVDGSW LDLAKRSKLE AQPFAHLTIN ATDIPSGSHK VSLSSWYHDR GWAKISNMTF SNGKLIVNQD GFYYLYANIC FRHHETSGDL ATEYLQLMVY VTKTSIKIPS SHTLMKGGST KYWSGNSEFH FYSINVGGFF KLRSGEEISI EVSNPSLLDP DQDATYFGAF KVRDID |
| Molecular Weight | 20 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 98% by SDS-PAGE gel and HPLC analyses |
| Endotoxin Concentration | < 0.1 EU/µg |
| Activity | Dose-dependent induction of reporter gene in HT-29 NF-κB Luc reporter cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
Recombinant Human sRANK Ligand is a 20.0 kDa polypeptide comprising the TNF-homologous region of RANKL (176 amino acid residues).
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which acts as a ligand for osteoprotegerin, functioning as a key factor in osteoclast differentiation and activation. It serves as a dendritic cell survival factor and regulates T cell-dependent immune responses.
T cell activation induces expression of this gene, promoting osteoclastogenesis and bone resorption. It activates antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and TRAF6, suggesting a role in apoptosis regulation.
Gene disruption in mice results in severe osteopetrosis, absence of osteoclasts, defects in T/B lymphocyte differentiation, and failure to form mammary structures during pregnancy. Two alternatively spliced transcript variants have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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