Thermo Fisher Scientific NAB2 Polyclonal Antibody
Thermo Fisher Scientific의 NAB2 Polyclonal Antibody는 인간 NAB2 단백질을 인식하는 토끼 유래 항체입니다. Western blot 및 Immunoprecipitation에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 핵 내 NAB2 단백질 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 475 and 525 of human NGFI-A Binding Protein 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
Transcriptional control is partly regulated by interactions between DNA-bound transcription factors such as Egr-1/NGFI-A and coregulatory proteins like NAB (NGFI-A-binding proteins). The conserved NAB proteins, NAB1 and NAB2, act as corepressors of EGF-1/NGFI-A. Both contain:
- NCD1 domain (NAB conserved domain 1): required for NGFI-A binding
- NCD2 domain: responsible for repressor function
NAB2 is primarily localized in the nucleus and may regulate NGFI-A activity, influencing cell division, differentiation, and apoptosis.
It has a predicted molecular mass of 56 kDa and is located on chromosome 12q13.3–14.1, a region associated with several solid tumors, lipomas, and liposarcomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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