Thermo Fisher Scientific IL-10 Monoclonal Antibody (JES3-9D7), PE

Applications

Tested Dilution

Publications

Immunohistochemistry (Frozen) (IHC (F))

-

View 1 publication 1 publication

Flow Cytometry (Flow)

5 µL / 1x10^6 cells

View 2 publications 2 publications

Miscellaneous PubMed (Misc)

-

View 6 publications 6 publications

Product Specifications

Published species

Human, Non-human primate, Rhesus monkey

Host/Isotype

Rat / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

JES3-9D7

Immunogen

Recombinant human Interleukin 10.

Conjugate

PE PE PE

View additional formats

• Unconjugated
• FITC
• Request custom conjugation

Excitation/Emission Max

565/576 nm View spectra

Form

Liquid

Storage conditions

4° C

Shipping conditions

Wet ice

RRID

AB_10375154

Target Information

IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.