Thermo Fisher Scientific ZDHHC16 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Immunogen sequence:
VLISRGETSI ERHINKKERR RLQAKGRVFR NPYNYGCLDN WKVFLGVDTG RHWLTRVLLP SSHLPHGNGM SWEPPPWVTA

Highest antigen sequence identity to the following orthologs:

• Mouse: 99%
• Rat: 99%

Target Information

ZDHHC16 (zinc finger, DHHC-type containing 16), also known as APH2, is a 377 amino acid multi-pass membrane protein that localizes to the endoplasmic reticulum and contains one DHHC-type zinc finger. Existing as multiple alternatively spliced isoforms, ZDHHC16 interacts with c-Abl and catalyzes the conversion of Palmitoyl-CoA and protein-cysteine to S-palmitoyl protein and CoA. Through its association with c-Abl, ZDHHC16 may be involved in the regulation of apoptosis. The gene encoding ZDHHC16 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2, and porphyria.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.