Thermo Fisher Scientific FMR1 Monoclonal Antibody (OTI5B9), TrueMAB
FMR1 단백질을 표적으로 하는 Mouse IgG1 단일클론 항체로, Western blot, IHC, ICC, Flow cytometry에 적합합니다. 인간 시료 반응성이 있으며, 동결건조 형태로 제공됩니다. 연구용으로 RNA 결합 및 Fragile X 관련 연구에 활용 가능합니다.
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Thermo Fisher Scientific FMR1 Monoclonal Antibody (OTI5B9), TrueMAB
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5B9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 36–279 of human FMR1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
FMR1 binds RNA and is associated with polysomes. It may participate in mRNA trafficking between the nucleus and cytoplasm.
A trinucleotide repeat in the 5′ UTR (normally 6–53 copies) expanded to 55–230 repeats causes Fragile X syndrome and may also lead to premature ovarian failure.
Multiple alternatively spliced transcript variants encoding different isoforms located in distinct cellular compartments have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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