Thermo Fisher Scientific TRPM4 Monoclonal Antibody (OTI14C3)
TRPM4 단백질을 표적으로 하는 Thermo Fisher Scientific의 단클론 항체. Western blot 및 IHC(P) 실험에 적합하며, 인간 시료 반응성. 액상 형태로 제공되며, 고순도 친화 크로마토그래피 정제. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI14C3 |
| Immunogen | Full-length protein expressed in 293T cells transfected with human TRPM4 expression vector |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.7 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725586 |
Target Information
Calcium-activated non-selective (CAN) cation channel that mediates membrane depolarization. Activated by intracellular Ca²⁺ increase but impermeable to it. Mediates transport of monovalent cations (Na⁺, K⁺, Cs⁺, Li⁺), leading to membrane depolarization. Plays key roles in cardiomyocytes, neurons (entorhinal cortex, dorsal root, vomeronasal), endocrine pancreas cells, kidney epithelial cells, cochlea hair cells, and others.
Participates in T-cell activation by modulating Ca²⁺ oscillations required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries and controls insulin secretion in pancreatic beta-cells. May contribute to pacemaking or irregular electrical activity under Ca²⁺ overload. Affects Th1/Th2 cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation via β-catenin signaling pathway upregulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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