ELK Biotechnology EGF Receptor (phospho-Tyr1148) rabbit pAb
EGF Receptor (phospho-Tyr1148) rabbit pAb는 EGFR의 Tyr1148 인산화를 특이적으로 검출하는 폴리클로날 항체입니다. Western blot에 적합하며, 인간·쥐·마우스 시료에서 반응합니다. 세포막 및 세포내 수송 경로 연구에 유용합니다.
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EGF Receptor (phospho-Tyr1148) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | EGF Receptor (phospho-Tyr1148) rabbit pAb |
| Alternative Names | Epidermal growth factor receptor (EC 2.7.10.1), Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1 |
| Applications | WB |
| Recommended Dilutions | WB 1:1000–2000 |
| Immunogen | Synthesized phospho peptide around human EGF Receptor (Tyr1148) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 134 kDa |
| GeneID (Human) | 1956 |
| Human Swiss-Prot No | P00533 |
| Species Reactivity | Human, Rat, Mouse |
Cellular Localization
Cell membrane (Single-pass type I membrane protein), Endoplasmic reticulum membrane, Golgi apparatus membrane, Nucleus membrane, Endosome.
In response to EGF, EGFR translocates from the cell membrane to the nucleus via Golgi and ER (PubMed:20674546, 17909029).
Endocytosed upon activation by ligand (PubMed:2790960, 17182860, 27153536, 17909029).
Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (PubMed:20551055).
Isoform 2: Secreted.
Background
The protein encoded by this gene is a transmembrane glycoprotein belonging to the protein kinase superfamily. It functions as a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds epidermal growth factor, inducing receptor dimerization and tyrosine autophosphorylation, leading to cell proliferation. Mutations in this gene are associated with lung cancer. (RefSeq, Jun 2016)
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