ELK Biotechnology EGF Receptor (phospho-Tyr845) rabbit pAb
EGFR의 Tyr845 인산화 형태를 인식하는 rabbit polyclonal 항체로, WB에 적합합니다. 세포막 및 다양한 세포 소기관에 위치한 EGFR 단백질 검출에 사용됩니다. 고순도 IgG, 1 mg/ml 농도로 제공되며 -20°C에서 1년간 보관 가능합니다.
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EGF Receptor (phospho-Tyr845) Rabbit pAb
제품 개요
EGFR의 Tyr845 잔기에 대한 인산화 특이적 rabbit polyclonal 항체입니다. 세포 내 신호전달 연구 및 EGFR 활성화 상태 분석에 유용합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | EGF Receptor (phospho-Tyr845) rabbit pAb |
| Alternative Names | Epidermal growth factor receptor (EC 2.7.10.1), Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1 |
| Applications | WB |
| Recommended Dilutions | WB 1:1000–2000 |
| Immunogen | Synthesized phospho peptide around human EGF Receptor (Tyr845) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 134 kDa |
| Gene ID (Human) | 1956 |
| Human Swiss-Prot No. | P00533 |
| Species Reactivity | Human, Rat, Mouse |
세포 내 위치 (Cellular Localization)
Cell membrane; Single-pass type I membrane protein.
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Golgi apparatus membrane; Single-pass type I membrane protein.
Nucleus membrane; Single-pass type I membrane protein.
Endosome; Endosome membrane.
Nucleus.
In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER (PubMed:20674546, PubMed:17909029).
Endocytosed upon activation by ligand (PubMed:2790960, PubMed:17182860, PubMed:27153536, PubMed:17909029).
Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (PubMed:20551055).
Isoform 2: Secreted.
Background
The protein encoded by this gene is a transmembrane glycoprotein and a member of the protein kinase superfamily. It acts as a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor; binding induces receptor dimerization and tyrosine autophosphorylation, leading to cell proliferation. Mutations in this gene are associated with lung cancer.
[provided by RefSeq, Jun 2016]
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