ELK Biotechnology EGF Receptor (phospho-Tyr992) rabbit pAb

EGF Receptor (phospho-Tyr992) rabbit pAb

제품 개요

EGF Receptor (phospho-Tyr992) rabbit pAb은 인간 및 생쥐 시료에서 EGFR의 Tyr992 인산화 형태를 검출하기 위한 폴리클로날 항체입니다. 본 항체는 세포막 및 다양한 세포 소기관에 존재하는 EGFR 단백질의 위치 및 발현을 분석하는 데 사용됩니다.

제품 정보

세포 내 위치

Cell membrane; Single-pass type I membrane protein.
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Golgi apparatus membrane; Single-pass type I membrane protein.
Nucleus membrane; Single-pass type I membrane protein.
Endosome; Endosome membrane.
Nucleus.
In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER (PubMed:20674546, PubMed:17909029).
Endocytosed upon activation by ligand (PubMed:2790960, PubMed:17182860, PubMed:27153536, PubMed:17909029).
Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (PubMed:20551055).
Isoform 2: Secreted.

Background

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein acts as a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, and binding induces receptor dimerization and tyrosine autophosphorylation, leading to cell proliferation. Mutations in this gene are associated with lung cancer. (Provided by RefSeq, Jun 2016)