ELK Biotechnology FBW1A rabbit pAb
FBW1A 단백질을 인식하는 토끼 폴리클로날 항체로, WB 실험에 적합합니다. 인간 및 마우스 시료에 반응하며, 세포질과 핵에 위치한 단백질 검출에 사용됩니다. -20°C에서 1년간 안정적으로 보관 가능합니다.
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ELK Biotechnology FBW1A rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | FBW1A rabbit pAb |
| Applications | WB |
| Recommended Dilutions | WB 1:500–2000 |
| Immunogen | Synthesized peptide derived from human FBW1A (AA range: 43–93) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 8945 |
| Human Swiss-Prot No. | Q9Y297 |
| Cellular Localization | Cytoplasm, Nucleus |
| Species Reactivity | Human, Mouse |
Background
This gene encodes a member of the F-box protein family, characterized by an approximately 40 amino acid F-box motif. F-box proteins are components of the SCF (SKP1–Cullin–F-box) ubiquitin ligase complex, which mediates phosphorylation-dependent ubiquitination. They are classified into three types:
- Fbws: containing WD-40 domains
- Fbls: containing leucine-rich repeats
- Fbxs: containing other interaction modules or no recognizable motifs
The FBW1A protein belongs to the Fbws class, containing multiple WD-40 repeats. It mediates CD4 degradation through interaction with HIV-1 Vpu and ubiquitinates phosphorylated NFKBIA, leading to its degradation and activation of NF-κB. Alternatively spliced transcript variants and a related pseudogene on chromosome 6 have been identified.
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