ELK Biotechnology FBX22 rabbit pAb
FBX22 단백질을 인식하는 토끼 폴리클로날 항체로, WB 실험에 적합합니다. 인체 및 마우스 시료에 반응하며, p53 유도 단백질 분해 관련 연구에 유용합니다. -20°C에서 1년 보관 가능합니다.
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- pk
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제품명
FBX22 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | WB |
| Recommended Dilutions | WB 1:500–2000 |
| Immunogen | Synthesized peptide derived from human FBX22 (AA 182–232) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 26263 |
| Human Swiss-Prot No. | Q8NEZ5 |
| Cellular Localization | Cytoplasm, myofibril, sarcomere, Z line |
| Species Reactivity | Human, Mouse |
Background
This gene encodes a member of the F-box protein family, characterized by an approximately 40 amino acid motif known as the F-box. F-box proteins form one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination.
F-box proteins are divided into three classes:
- Fbws containing WD-40 domains
- Fbls containing leucine-rich repeats
- Fbxs containing other protein–protein interaction modules or no recognizable motifs
The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants.
(Information provided by RefSeq, Dec 2010)
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