ELK Biotechnology FGF Receptor (phospho-Tyr653/654) rabbit pAb
FGF Receptor (phospho-Tyr653/654) rabbit pAb는 인산화된 FGFR1을 인식하는 폴리클로날 항체로, WB에 적합합니다. 세포막 및 핵 내 위치 분석에 활용되며, 높은 특이성과 재현성을 제공합니다. -20°C에서 1년 보관 가능합니다.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology FGF Receptor (phospho-Tyr653/654) rabbit pAb
FGF Receptor (phospho-Tyr653/654) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | FGF Receptor (phospho-Tyr653/654) rabbit pAb |
| Alternative Names | Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1), Basic fibroblast growth factor receptor 1 (BFGFR), bFGF-R-1, Fms-like tyrosine kinase 2 (FLT-2), N-sam, Proto-oncogene c-Fgr, CD antigen CD331 |
| Applications | WB |
| Recommended Dilutions | WB 1:1000–2000 |
| Immunogen | Synthesized phospho peptide around human FGF Receptor (Tyr653 and 654) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 120 kD |
| Gene ID (Human) | 2260 |
| Human Swiss-Prot No. | P11362 |
| Species Reactivity | Human, Rat, Mouse |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle. After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus. |
Background
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution.
A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain.
The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation.
This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome and Jackson-Weiss syndrome.
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.