ELK Biotechnology FLNC rabbit pAb
FLNC 단백질을 인식하는 토끼 폴리클로날 항체로, IHC 및 IF 실험에 적합합니다. 사람 및 생쥐 시료에 반응하며, 세포질 및 근절 Z선에서 주로 발현됩니다. 고순도의 IgG 형식으로 -20°C에서 1년간 보관 가능합니다.
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제품명
FLNC rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | IHC; IF |
| Recommended Dilutions | IHC-p 1:50–200 |
| Immunogen | Synthesized peptide derived from human FLNC (AA range: 335–385) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 2318 |
| Human Swiss-Prot No. | Q14315 |
| Species Reactivity | Human; Mouse |
세포 내 위치
Cytoplasm, Membrane, Peripheral membrane protein, Cytoplasm (cytoskeleton, myofibril, sarcomere, Z line).
A small amount localizes at membranes.
In striated muscle cells, it predominantly localizes in myofibrillar Z lines, while a minor fraction localizes with subsarcolemma.
Targeting to developing and mature Z lines is mediated by the intradomain insert.
Background
This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton.
Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain.
Two transcript variants encoding different isoforms have been found for this gene.
[provided by RefSeq, Jul 2008]
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