ELK Biotechnology FLT3 (phospho-Tyr591) rabbit pAb

FLT3 (phospho-Tyr591) Rabbit Polyclonal Antibody

제품 개요

FLT3 (phospho-Tyr591) rabbit pAb는 인간 FLT3 단백질의 인산화된 Tyr591 부위를 인식하도록 제작된 폴리클로날 항체입니다. FLT3는 조혈세포의 증식, 분화, 생존에 중요한 역할을 하는 class III receptor tyrosine kinase로, 변이 시 급성 백혈병과 관련이 있습니다.

제품 정보

세포 내 위치 (Cellular Localization)

Membrane; Single-pass type I membrane protein.
Endoplasmic reticulum lumen.
Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation.

배경 (Background)

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. Activation occurs via binding of the FLT3 ligand to the extracellular domain, inducing homodimer formation and autophosphorylation. The activated receptor phosphorylates and activates cytoplasmic effectors involved in apoptosis, proliferation, and differentiation of hematopoietic cells. Mutations causing constitutive activation are implicated in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). [RefSeq, Jan 2015]