ELK Biotechnology FoxO3a (phospho-Ser294) rabbit pAb

FoxO3a (phospho-Ser294) rabbit pAb

제품 개요

FoxO3a (phospho-Ser294) rabbit polyclonal antibody는 Forkhead box protein O3의 Ser294 인산화 부위를 인식하는 항체로, 세포 내 신호전달 및 인산화 조절 연구에 유용합니다.

제품 정보

세포 내 위치 (Cellular Localization)

• Cytoplasm, cytosol, nucleus, mitochondrion matrix, mitochondrion outer membrane (cytoplasmic side)
• Retention in the cytoplasm contributes to its inactivation (PubMed:10102273, PubMed:15084260, PubMed:16751106)
• Translocates to the nucleus upon oxidative stress and in the absence of survival factors (PubMed:10102273, PubMed:16751106)
• Translocates from the cytosol to the nucleus following dephosphorylation in response to autophagy-inducing stimuli (By similarity)
• Translocates in an AMPK-dependent manner into the mitochondrion in response to metabolic stress (PubMed:23283301, PubMed:29445193)
• Serum deprivation increases localization to the nucleus, leading to activation of SOX9 expression and subsequent chondrogenesis (By similarity)

Background

This gene belongs to the forkhead family of transcription factors characterized by a distinct forkhead domain. It likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [RefSeq, Jul 2008]