ELK Biotechnology FoxO3a (phospho-Ser425) rabbit pAb

제품명

FoxO3a (phospho-Ser425) rabbit pAb

대체 명칭

Forkhead box protein O3 (AF6q21 protein), Forkhead in rhabdomyosarcoma-like 1

적용 분야

• WB (Western Blot)

권장 희석 배수

• WB: 1:1000–2000

면역원

• Synthesized phospho peptide around human FoxO3a (Ser425)

저장 조건

• -20°C / 1년 안정
• Host: Rabbit

클론 특성

세포 내 위치

Cytoplasm, cytosol, nucleus, mitochondrion matrix, mitochondrion outer membrane (peripheral membrane protein, cytoplasmic side).
Retention in the cytoplasm contributes to its inactivation (PubMed:10102273, 15084260, 16751106).
Translocates to the nucleus upon oxidative stress and in the absence of survival factors (PubMed:10102273, 16751106).
Translocates from the cytosol to the nucleus following dephosphorylation in response to autophagy-inducing stimuli (By similarity).
Translocates in an AMPK-dependent manner into the mitochondrion in response to metabolic stress (PubMed:23283301, 29445193).
Serum deprivation increases localization to the nucleus, leading to activation of SOX9 expression and subsequent chondrogenesis (By similarity).

배경 정보

This gene belongs to the forkhead family of transcription factors characterized by a distinct forkhead domain.
It likely functions as a trigger for apoptosis through expression of genes necessary for cell death.
Translocation of this gene with the MLL gene is associated with secondary acute leukemia.
Alternatively spliced transcript variants encoding the same protein have been observed.
[provided by RefSeq, Jul 2008]