ELK Biotechnology FoxO3a (phospho-Ser7) rabbit pAb
FoxO3a (phospho-Ser7) rabbit polyclonal antibody로 세포 내 FoxO3a 단백질의 인산화 상태를 검출. WB에 적합하며 Human, Mouse, Rat 반응성. Apoptosis 및 세포 스트레스 관련 연구에 활용 가능.
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제품명
FoxO3a (phospho-Ser7) rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | Forkhead box protein O3 (AF6q21 protein), Forkhead in rhabdomyosarcoma-like 1 |
| Applications | WB |
| Recommended Dilutions | WB 1:1000–2000 |
| Immunogen | Synthesized phospho peptide around human FoxO3a (Ser7) |
| Species Reactivity | Human, Mouse, Rat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 90 kD |
| GeneID (Human) | 2309 |
| Human Swiss-Prot No | O43524 |
| Storage | -20°C / 1 year |
| Host | Rabbit |
세포 내 위치 (Cellular Localization)
Cytoplasm, cytosol, nucleus, mitochondrion matrix, mitochondrion outer membrane; peripheral membrane protein (cytoplasmic side).
Retention in the cytoplasm contributes to inactivation (PubMed:10102273, 15084260, 16751106).
Translocates to the nucleus upon oxidative stress or absence of survival factors (PubMed:10102273, 16751106).
Translocates from cytosol to nucleus following dephosphorylation in response to autophagy-inducing stimuli (By similarity).
Translocates in an AMPK-dependent manner into mitochondrion under metabolic stress (PubMed:23283301, 29445193).
Serum deprivation increases nuclear localization, activating SOX9 expression and subsequent chondrogenesis (By similarity).
Background
This gene belongs to the forkhead family of transcription factors characterized by a distinct forkhead domain.
It likely functions as a trigger for apoptosis through expression of genes necessary for cell death.
Translocation of this gene with the MLL gene is associated with secondary acute leukemia.
Alternatively spliced transcript variants encoding the same protein have been observed.
[provided by RefSeq, Jul 2008]
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