ELK Biotechnology FoxO3a (phospho-Ser7) rabbit pAb

제품명

FoxO3a (phospho-Ser7) rabbit pAb

기본 정보

세포 내 위치 (Cellular Localization)

Cytoplasm, cytosol, nucleus, mitochondrion matrix, mitochondrion outer membrane; peripheral membrane protein (cytoplasmic side).
Retention in the cytoplasm contributes to inactivation (PubMed:10102273, 15084260, 16751106).
Translocates to the nucleus upon oxidative stress or absence of survival factors (PubMed:10102273, 16751106).
Translocates from cytosol to nucleus following dephosphorylation in response to autophagy-inducing stimuli (By similarity).
Translocates in an AMPK-dependent manner into mitochondrion under metabolic stress (PubMed:23283301, 29445193).
Serum deprivation increases nuclear localization, activating SOX9 expression and subsequent chondrogenesis (By similarity).

Background

This gene belongs to the forkhead family of transcription factors characterized by a distinct forkhead domain.
It likely functions as a trigger for apoptosis through expression of genes necessary for cell death.
Translocation of this gene with the MLL gene is associated with secondary acute leukemia.
Alternatively spliced transcript variants encoding the same protein have been observed.
[provided by RefSeq, Jul 2008]