ELK Biotechnology GluR-2 (Phospho-Tyr876) rabbit pAb

GluR-2 (Phospho-Tyr876) rabbit pAb

제품 정보

세포 내 위치 (Cellular Localization)

Cell membrane; multi-pass membrane protein. Endoplasmic reticulum membrane; multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; multi-pass membrane protein. Cell junction, synapse, postsynaptic density membrane; multi-pass membrane protein.
Interaction with CACNG2, CNIH2, and CNIH3 promotes cell surface expression (By similarity). Displays a somatodendritic localization and is excluded from axons in neurons (By similarity).

Background

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes.
This gene product belongs to a family of glutamate receptors sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and functions as a ligand-activated cation channel.
These channels are assembled from four related subunits, GRIA1–4. The subunit encoded by this gene (GRIA2) undergoes RNA editing (CAG→CGG; Q→R) within the second transmembrane domain, rendering the channel impermeable to Ca²⁺.
Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology.
Alternative splicing results in transcript variants encoding different isoforms.