ELK Biotechnology HER2 (Phospho-Tyr1139) rabbit pAb
HER2 (Phospho-Tyr1139) rabbit pAb는 인간, 마우스, 랫트에서 반응하는 다클론 항체로, IHC, IF, WB에 적합합니다. 인산화된 HER2 Tyr1139 부위에 특이적이며 세포막 및 핵 내 위치 연구에 활용됩니다. 고순도 IgG, 1 mg/ml 농도, -20°C에서 1년 보관 가능합니다.
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제품명
HER2 (Phospho-Tyr1139) rabbit pAb
공급업체
ELK Biotechnology
제품 설명
HER2 (Phospho-Tyr1139) rabbit pAb는 인간 HER2 단백질의 인산화 Tyr1139 부위에서 유래한 합성 펩타이드를 면역원으로 제작된 다클론 항체입니다. HER2 신호전달 및 암 관련 연구에 유용하며, IHC, IF, WB 등 다양한 응용에 적합합니다.
스펙 정보
| 항목 | 내용 |
|---|---|
| Product name | HER2 (Phospho-Tyr1139) rabbit pAb |
| Alternative Names | Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD antigen CD340) |
| Applications | IHC; IF; WB |
| Recommended Dilutions | IHC-p 1:50–200, WB 1:500–2000 |
| Immunogen | Synthesized peptide derived from human HER2 (Phospho-Tyr1139) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 180 kD |
| GeneID (Human) | 2064 |
| Human Swiss-Prot No | P04626 |
| Cellular Localization | Isoform 1: Cell membrane; Single-pass type I membrane protein; Early endosome; Cytoplasm (perinuclear region); Nucleus. Translocation to the nucleus requires endocytosis, mediated by importin beta-1/KPNB1. Also detected in VPS35-positive endosome-to-TGN retrograde vesicles (PubMed:31138794). Isoform 2: Cytoplasm, Nucleus. Isoform 3: Cytoplasm, Nucleus. |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein lacks its own ligand-binding domain and therefore cannot bind growth factors directly. It forms heterodimers with other ligand-bound EGF receptor family members, stabilizing ligand binding and enhancing downstream signaling pathways such as MAPK and PI3K. Amplification and/or overexpression of this gene has been reported in various cancers including breast and ovarian tumors. Alternative splicing results in multiple transcript variants.
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