Thermo Fisher Scientific IL1F6 Polyclonal Antibody
인간, 마우스, 랫트 반응성의 IL1F6 폴리클로날 항체로, Western blot에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 고순도(>95%)를 보장합니다. IL-36α 관련 염증 및 신호전달 연구용으로 사용됩니다.
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Thermo Fisher Scientific IL1F6 Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein of human IL36A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803807 |
Product Specific Information
Purity is greater than 95% by SDS-PAGE.
Target Information
The IL-1 family comprises 11 structurally related ligands, including IL-36α (IL-1F6), IL-36β (IL-1F8), and IL-36γ (IL-1F9).
IL-36α is highly expressed in psoriatic plaques and uniquely expressed by T cells, monocytes, and B cells. It is primarily found in skin and lymphoid tissues, with lower expression in fetal brain, trachea, stomach, and intestine.
IL-36α signals through IL-1Rrp2 (IL-1R6) and IL-RAcP receptors, activating NF-κB and MAPK pathways to induce proinflammatory cytokines and chemokines such as IL-6, IL-8, BD-2, and BD-3.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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