Thermo Fisher Scientific ROR1 Polyclonal Antibody

Thermo Fisher Scientific ROR1 Polyclonal Antibody

Applications and Tested Dilution

• Immunohistochemistry (Paraffin) (IHC (P)): 4–6 µg/mL

Product Specifications

Product Specific Information

• Expected to recognize isoform 1 (NP_005003.2) only.
• Tested in Peptide ELISA: antibody detection limit dilution 1:16,000.

Target Information

Receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) is a tumor-associated surface protein predominantly expressed during embryogenesis, where it is involved in organ morphogenesis, nervous system development, and neural progenitor cell maintenance and survival.
Virtually absent from normal pediatric and adult tissues, except for low-level expression in hematogones and adipocytes, ROR1 is notably overexpressed and considered a survival factor in several malignancies, including:

• Chronic lymphocytic leukemia (CLL)
• Mantle cell lymphoma (MCL)
• Acute lymphoblastic leukemia (ALL)
• Marginal zone lymphoma
• Lung adenocarcinoma

ROR1 was initially identified during PCR-based cloning of a human neuroblastoma cell line searching for tyrosine kinases similar to tropomyosin-receptor-kinase (Trk) receptors. Along with ROR2, it was categorized as an orphan receptor due to unknown ligand association.
Wnt-5a has since been suggested as a candidate ligand, and ROR1 may function as a pseudokinase, promoting proliferation and resistance to apoptosis in cancer cells through Wnt-5a interaction and TCL1 co-activation of AKT.
ROR1 is expressed as a glycoprotein containing extracellular immunoglobulin (Ig)-like, Frizzled, and Kringle domains, as well as an intracellular tyrosine kinase domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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