
Thermo Fisher Scientific ROR1 Polyclonal Antibody
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Applications
Tested Dilution
Publications
Immunohistochemistry (Paraffin) (IHC (P))
4-6 µg/mL
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat / IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-GNKSQKPYKIDSKQA. if (typeof window.$mangular === undefined
|| !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{
targetFamily:
ROR1,
uniProtId:
Q01973-1,
ncbiNodeId:
9606,
antigenRange:
903-917,
antigenLength:
937,
antigenImageFileName:
PA5-142446_ROR1_Q01973-1_Goat.svg,
antigenImageFileNamePDP:
PA5-142446_ROR1_Q01973-1_Goat_PDP.jpeg,
sortOrder:
1}\]
; $mangular.isB2BCMGT = false
; $mangular.isEpitopesModalImageMultiSizeEnabled = true
;
View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}
Conjugate
Unconjugated Unconjugated Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2933094
Product Specific Information
Additional Information: This antibody is expected to recognize isoform 1 (NP_005003.2) only.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:16,000.
Target Information
Receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) is a tumor-associated, surface protein predominantly expressed during embryogenesis, where it is involved in organ morphogenesis, nervous system development, and neural progenitor cell maintenance and survival. Virtually absent from normal pediatric and adult tissues, with the exception of low-level expression in a subset of immature b cell precursors known as hematogones and adipocytes, ROR1 is notably overexpressed, and considered a survival factor, in a number of B lymphoid and epithelial malignancies: including chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), acute lymphoblastic leukemia (ALL), marginal zone lymphoma, lung adenocarcinoma. First identified during PCR-based cloning of a human neuroblastoma cell line in search of tyrosine kinases similar to tropomyosin-receptor-kinase (Trk) neurotropic receptors, ROR1, along with the related receptor tyrosine kinase (RTK) ROR2, was catalogued as an orphan
receptor due to the fact its related ligand remained elusive. Wnt-5a has since been suggested as a candidate ligand for ROR1, and ROR1 has been implicated to function as a pseudokinase, promoting proliferation and resistance to apoptosis in cancer cells through interaction with Wnt-5a, and TCL1-co-activation of AKT. ROR1 is expressed as a glycoprotein containing extracellular immunoglobulin (Ig)-like, Frizzled, and Kringle domains, as well as an intracellular region containing a tyrosine kinase domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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