Thermo Fisher Scientific TOB1 Polyclonal Antibody
Rabbit polyclonal antibody against human TOB1 protein for IHC and ICC applications. High specificity and affinity purified. Suitable for research on cell proliferation and cytokine regulation. Supplied in liquid form with glycerol and sodium azide for ...
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human TOB1. Recombinant protein control fragment (Product #RP-106155) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2662929 |
Product Specific Information
Immunogen sequence:
STKMKNSGRSN KVARTSPINL GLNVNDLLKQ KAISSSMHSL YGLGLGSQQQ PQQQ
Highest antigen sequence identity to orthologs:
- Mouse: 91%
- Rat: 91%
Target Information
This gene encodes a member of the tob/btg1 family of anti-proliferative proteins that regulate cell growth. When exogenously expressed, TOB1 suppresses cell growth in tissue culture and is phosphorylated by serine/threonine kinase 90 kDa ribosomal S6 kinase. Interaction with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. TOB1 inhibits T cell proliferation and transcription of cytokines and cyclins, and interacts with SMAD2 and SMAD4 to enhance DNA binding activity, thereby inhibiting interleukin 2 transcription in T cells.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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