Thermo Fisher Scientific Ataxin 2 Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 0.2–1 µg/mL

Product Specifications

Product Specific Information

• Peptide sequence: HAPMMLMTTQ PPGGPQAALA QSALQPIPVS TTAHFPYMTH PSVQAHHQQQ
• Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%

Target Information

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem, and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I–III.
Defects in this gene are the cause of spinocerebellar ataxia type 2 (SCA2). SCA2 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I), characterized by cerebellar ataxia with additional clinical features such as optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy, and dementia.
SCA2 is caused by expansion of a CAG repeat in the coding region of this gene. Longer expansions result in earlier onset of the disease. Alternatively spliced transcript variants encoding different isoforms have been identified, but their full-length sequences have not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.