Thermo Fisher Scientific ROR1 Monoclonal Antibody (2F8)
ROR1 단백질을 표적으로 하는 Thermo Fisher Scientific의 마우스 단클론 항체(2F8)입니다. Western blot 및 ELISA에 적합하며, 인간 시료에 반응합니다. PBS(pH 7.4) 용액 형태로 제공되며, -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2F8 |
| Immunogen | ROR1 (294–393 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein sequence:
ANCIRIGIPM ADPINKNHKC YNSTGVDYRG TVSVTKSGRQ CQPWNSQYPH THTFTALRFP ELNGGHSYCR NPGNQKEAPW CFTLDENFKS DLCDIPACGK
Target Information
Receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) is a tumor-associated surface protein predominantly expressed during embryogenesis, where it is involved in organ morphogenesis, nervous system development, and neural progenitor cell maintenance and survival. It is virtually absent from normal pediatric and adult tissues, except for low-level expression in immature B cell precursors (hematogones) and adipocytes.
ROR1 is notably overexpressed and considered a survival factor in several B lymphoid and epithelial malignancies, including chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), acute lymphoblastic leukemia (ALL), marginal zone lymphoma, and lung adenocarcinoma.
Initially identified through PCR-based cloning in neuroblastoma cells, ROR1 was classified as an “orphan” receptor due to its unknown ligand. Wnt-5a has since been proposed as a candidate ligand, and ROR1 functions as a pseudokinase, promoting proliferation and resistance to apoptosis in cancer cells via Wnt-5a interaction and TCL1-mediated AKT co-activation.
ROR1 is expressed as a glycoprotein with extracellular immunoglobulin-like, Frizzled, and Kringle domains, and an intracellular tyrosine kinase domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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