Thermo Fisher Scientific DKC1 Polyclonal Antibody
Rabbit polyclonal antibody against human DKC1 protein. Validated for Western blot and immunoprecipitation. Targets residues 390–440 of DKC1. Supplied as liquid, 0.2 mg/mL, stored at 4°C. For research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 5–15 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 390 and 440 of human dyskeratosis congenita 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
This gene is a member of the H/ACA snoRNPs gene family, which is involved in rRNA processing and modification. The H/ACA snoRNPs include the NOLA1, NOLA2, and NOLA3 proteins. The DKC1 protein and these NOLA proteins localize to the dense fibrillar components of nucleoli and to coiled bodies in the nucleus. Depletion of any of these four proteins impairs 18S rRNA production and rRNA pseudouridylation. These proteins are also components of the telomerase complex.
The DKC1 gene is related to Saccharomyces cerevisiae Cbf5p and Drosophila melanogaster Nop60B proteins. Mutations in DKC1 cause X-linked dyskeratosis congenita, characterized by skin pigmentation, mucosal leukoplakia, nail dystrophy, and bone marrow failure, as well as Hoyeraal-Hreidarsson syndrome, a more severe form of the disease. Two transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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