Thermo Fisher Scientific Syncollin Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human Syncollin. Recombinant protein control fragment (Product #RP-99213). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Syncollin,uniProtId:Q0VAF6-1,ncbiNodeId:9606,antigenRange:76-134,antigenLength:134,antigenImageFileName:PA5-61563_Syncollin_Q0VAF6-1_Rabbit.svg,antigenImageFileNamePDP:PA5-61563_Syncollin_Q0VAF6-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2648129

Product Specific Information

Immunogen sequence: TASSLVVAPR CELTVWSRQG KAGKTHKFSA GTYPRLEEYR RGILGDWSNA ISALYCRCP

Highest antigen sequence identity to the following orthologs: Mouse - 75%, Rat - 71%.

Target Information

Syncollin is a 134 amino acid, small peripheral membrane protein abundantly expressed in pancreatic acinar cells and is tightly associated with the lumenal side of the zymogen granule membrane. It contains intrachain disulfide bonds. Syncollin is also known to associate with lipid rafts in a cholesterol-dependent manner. In pancreatic acinar cells, syncollin helps in exocytosis and also plays a role in maturation and/or concentration of zymogens in zymogen granules. Reports suggest that syncollin may also have a pore-forming activity on membranes and regulate exocytosis insome exocrine tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.