Thermo Fisher Scientific TPSG1 Monoclonal Antibody (OTI1G1)
TPSG1 단백질을 인식하는 Mouse monoclonal antibody로, WB, IHC(P), Flow Cytometry에 적합합니다. 고순도 Affinity 정제 항체이며, PBS 기반 보존용액에 안정화되어 있습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1G1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 20–283 of TPSG1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.94 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725551 |
Target Information
Tryptase gamma, also known as serine protease 31 or transmembrane tryptase, is an enzyme encoded by the TPSG1 gene in humans. Tryptases belong to the trypsin-like serine protease family (peptidase family S1) and are enzymatically active only as heparin-stabilized tetramers, resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3, with four functional genes identified: alpha I, beta I, beta II, and gamma I. Each has allelic variants such as alpha II, beta III, and gamma II. Beta tryptases are mainly expressed in mast cells, whereas alpha-tryptases predominate in basophils. The TPSG1 gene differs from other tryptase family members by containing a C-terminal hydrophobic domain that may act as a membrane anchor. Tryptases are implicated in asthma and allergic or inflammatory disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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