Thermo Fisher Scientific SMCR8 Polyclonal Antibody
인간 SMCR8 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 및 ICC/IF에 사용 가능. 자가포식 및 mTORC1 신호 조절 연구에 적합하며, 항원 친화 크로마토그래피로 정제됨. PBS 기반 완충액에 40% 글리세롤 포함.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SMCR8 (Product #RP-93457) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2647631 |
Product Specific Information
Immunogen sequence:
FQASISPPEL GETEEGSIEN TPSQIDSSCC IGKESDGQLV LPSTPAHTHS DEDGVVSSPP QRHRQKDQGF RVDFSVENAN PSSRDNSCEG FPAY
Highest antigen sequence identity to the following orthologs:
- Mouse: 71%
- Rat: 73%
Target Information
SMCR8 is a component of the C9orf72–SMCR8 complex, which exhibits guanine nucleotide exchange factor (GEF) activity and regulates autophagy.
Within the complex, C9orf72 and SMCR8 likely act as catalytic subunits promoting the exchange of GDP to GTP, activating RAB8A and RAB39B, and facilitating autophagosome maturation.
The complex also negatively regulates autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its kinase activity.
Additionally, SMCR8 modulates mTORC1 signaling by promoting phosphorylation of its substrates.
In the nucleus, SMCR8 associates with chromatin and negatively regulates expression of ULK1 and WIPI2 genes.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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