Thermo Fisher Scientific CSF3 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

G-CSF (Granulocyte Colony Stimulating Factor) is a naturally occurring cytokine that stimulates the production and antibacterial function of neutrophils and monocytes. Human G-CSF is an 18.8 kDa protein containing 175 amino acid residues, and a soluble isoform of the G-CSF receptor has been described.
This pleiotropic cytokine is produced by activated monocytes, macrophages, endothelial cells, fibroblasts, astrocytes, osteoblasts, and bone marrow cells. G-CSF affects proliferation, differentiation, and activation of hematopoietic cells and is expressed by various transformed cells such as carcinoma and myeloblastic leukemia cells.
G-CSF is encoded by two distinct DNA sequences, resulting in a full-size, high-activity and a shorter, low-activity isoform. It is highly conserved among species and exerts biological functions through interaction with its receptor on hematopoietic progenitors, neutrophilic granulocytes, and certain carcinoma cell lines.
Clinically, G-CSF is used for treatment of neonatal infections, acute myocardial infarction, neutropenia, severe infections, sepsis, chronic autoimmune neutropenia, acute myeloid leukemia, Sweet’s syndrome, and AIDS. It also serves as a marker protein for various carcinomas and is linked to Kostmann Syndrome.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.