Thermo Fisher Scientific JMJD4 Polyclonal Antibody
JMJD4 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간 시료에 반응하며, IHC(P) 등 다양한 응용에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 항체로, 안정적 저장 및 높은 특이성 제공.
- 카탈로그번호
- PA5111363
- 판매단위
- pk
카탈로그
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein corresponding to Human JMJD4 (Product # RP-103137) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856773 |
Product Specific Information
Immunogen sequence:
GVGQAPGRVA FVSEPGAFSY ADFVRGFLLP NLPCVFSSAF TQGWGSRRRW VTPAGRPDFD HLLRTYGDVV VPVANCGVQE YNSNPKEHMT LRDYITYWKE YIQAGYSSPR GCLYLKDWHL CRDFPVEDVF TLPVYFSSDW LNEFWDA
Target Information
Covalent modification of histones plays a critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes has been identified that perform this specific function.
Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9).
Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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