Thermo Fisher Scientific p53R2 Recombinant Rabbit Monoclonal Antibody (074)
Human RRM2B/p53R2 특이적 재조합 토끼 단클론 항체로 높은 특이성과 민감도를 제공. Western blot에 적합하며 로트 간 일관성 유지. 보존제가 없으며 장기 보관 시 -20°C 권장.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific p53R2 Recombinant Rabbit Monoclonal Antibody (074)
Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 074 |
| Immunogen | Recombinant Human RRM2B/P53R2 protein (Met1–Phe351) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2785379 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide (final concentration 0.05%–0.1%) to avoid contamination.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning antibody DNA sequences from immunoreactive rabbits. Individual clones are screened for optimal production.
Advantages:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin–free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
This antibody has specificity for Human RRM2B/p53R2.
Target Information
The p53 tumor-suppressor gene integrates signals controlling cell life and death. Several molecules involved in p53 signaling, including p53R2, Chk2, p53AIP1, Noxa, PIDD, and PID/MTA2, have been discovered.
p53R2 is a p53-inducible gene containing a p53 binding sequence and encodes a subunit of ribonucleotide reductase. It is induced by UV and gamma irradiation that cause DNA damage and is directly involved in the p53 checkpoint for DNA repair.
The p73 isoform also induces p53R2 expression. Thus, p53R2 is an important target of p53 for tumor suppression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(해당 항체 항원 구조 이미지: MA5-29530_p53R2_Q7LG56-1_Rabbit.svg / MA5-29530_p53R2_Q7LG56-1_Rabbit_PDP.jpeg)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.