Thermo Fisher Scientific CD49d (Integrin alpha 4) Recombinant Rabbit Monoclonal Antibody (ARC0888)
CD49d (Integrin alpha 4) 단백질을 표적하는 Thermo Fisher Scientific의 재조합 토끼 단일클론 항체. WB, IHC, ELISA에 적합하며 인간, 마우스, 랫트 반응성. 고순도 Affinity Chromatography 정제, 안정적 PBS/glycerol buffer 저장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0888 |
| Immunogen | Synthetic peptide corresponding to amino acids 933–1032 of human Integrin alpha 4 (ITGA4/CD49d, UniProt ID: P13612) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849336 |
Product Specific Information
Immunogen sequence:
ALKFEIRATG FPEPNPRVIE LNKDENVAHV LLEGLHHQRP KRYFTIVIIS SSLLLGLIVL LLISYVMWKA GFFKRQYKSI LQEENRRDSW SYINSKSNDD
Target Information
Integrin alpha 4 (CD49d, ITGA4) is a member of the integrin alpha chain family. Integrins are heterodimeric membrane proteins composed of alpha and beta chains. The alpha4 chain associates with either beta1 or beta7, forming integrin alpha4beta1 and alpha4beta7 complexes. These complexes mediate cell adhesion via ligands such as MadCAM, VCAM, and fibronectin. MadCAM serves as the principal ligand for alpha4beta7, and HIV-1 envelope proteins can mimic MadCAM by binding to and signaling through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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