Thermo Fisher Scientific HOXA11 Polyclonal Antibody
HOXA11 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC, Flow Cytometry에 적합. 고순도 항원 친화 크로마토그래피 정제. 동결건조 형태로 제공되며 인체, 마우스, 랫트 반응성.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL |
| Immunohistochemistry (Frozen) (IHC (F)) | 0.5–1 µg/mL |
| Immunocytochemistry (ICC/IF) | 0.5–1 µg/mL |
| Flow Cytometry (Flow) | 1–3 µg/1×10⁶ cells |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E.coli-derived human HOXA11 recombinant protein (Position: H74–R245) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5 mg BSA |
| Contains | 0.05 mg sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2746503 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
HOX11, also called homeobox11 or Tcl-3, is located at the 10q24 T-cell translocation breakpoint region. It encodes a homeobox-domain containing protein with a glycine and proline-rich amino terminus. HOX11 is required for spleen development and cell survival, binding specific DNA sequences and localizing to the nucleus. It acts as a transcription activator and is highly expressed in T-ALLs due to chromosomal translocations such as t(7;10)(q35;q24) or t(10;14)(q24;q11). Deregulation of HOX11 is associated with T-cell leukemia and lymphoid neoplasias.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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