Thermo Fisher Scientific FBXO32 Polyclonal Antibody
FBXO32 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 인간 및 생쥐 시료에 반응합니다. Western blot, ICC/IF, ELISA에 적합하며, 고순도 친화 크로마토그래피 정제 제품입니다. 근위축 관련 연구에 활용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 3 publications |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
| ELISA | 1 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 206–355 of human Fbx32/FBOX32 (NP_4781361) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806344 |
Product Specific Information
Immunogen sequence:
WQQQLNNIQI TRPAFKGLTF TDLPLCLQLN IMQRLSDGRD LVSLGQAAPD LHVLSEDRLL WKKLCQYHFS ERQIRKRLIL SDKGQLDWKK MYFKLVRCYP RKEQYGDTLQ LCKHCHILSW KGTDHPCTAN NPESCSVSLS PQDFINLFKF
Target Information
This gene encodes a member of the F-box protein family, characterized by an approximately 40 amino acid F-box motif. F-box proteins are one of the four subunits of the ubiquitin protein ligase complex (SCFs), which function in phosphorylation-dependent ubiquitination.
F-box proteins are divided into three classes:
- Fbws: containing WD-40 domains
- Fbls: containing leucine-rich repeats
- Fbxs: containing other protein-protein interaction modules or no recognizable motifs
The encoded protein belongs to the Fbxs class and contains an F-box domain. It is highly expressed during muscle atrophy, and mice deficient in this gene are resistant to atrophy. Therefore, this protein is a potential drug target for the treatment of muscle atrophy. Alternative splicing results in two transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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