Thermo Fisher Scientific Human IL-22 Recombinant Protein, PeproTech
Human IL-22 recombinant protein for functional and in vitro assays; expressed in E. coli with ≥98% purity; activates STAT and induces IL-10 secretion; supplied lyophilized and stored at -20°C; suitable for cytokine signaling research.
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Applications
Western Blot (WB)
- Tested Dilution: Assay-dependent
- Publications: View 1 publication
ELISA
- Tested Dilution: Assay-dependent
- Publications: View 1 publication
Functional Assay
- Tested Dilution: Assay-dependent
- Publications: View 1 publication
In vitro Assay (IV)
- Publications: View 29 publications
Miscellaneous PubMed
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published Species | Human, Mouse, Non-human primate |
| Expression System | E. coli |
| Amino Acid Sequence | MAPISSHCRL DKSNFQQPYI TNRTFMLAKE ASLADNNTDV RLIGEKLFHG VSMSERCYLM KQVLNFTLEE VLFPQSDRFQ PYMQEVVPFL ARLSNRLSTC HIEGDDLHIQ RNVQKLKDTV KKLGESGEIK AIGELDLLFM SLRNACI |
| Molecular Weight | 33.6 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 98% by SDS-PAGE gel and HPLC analyses |
| Endotoxin Concentration | <1 EU/µg |
| Activity | Assay 1: Activates STAT following receptor-ligand interaction. Assay 2: Induces IL-10 secretion in COLO 205 cells (ED50: 0.7–1.0 ng/ml) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
Recombinant Human IL-22 is a 33.6 kDa, non-disulfide-linked, homodimeric protein consisting of two 147 amino acid polypeptide chains.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
IL-22, also known as IL-10-related T-cell derived inducible factor, is an alpha-helical cytokine and a member of the IFN–IL-10 family (including IL-19, IL-20, IL-24, IL-26, IL-28, IL-29, and type I/II interferons).
Produced mainly by activated T cells and NK cells, IL-22 gene is located on chromosome 12q and structurally related to IL-10.
It acts through the heterodimeric receptor complex IL-22R1 and IL-10R2, triggering JAK-STAT pathway signaling.
A soluble IL-22 receptor (IL-22BP) antagonizes IL-22 binding and signaling.
IL-22 primarily targets nonimmune cells such as skin, digestive, respiratory epithelial cells, hepatocytes, and keratinocytes.
It functions as an effector cytokine of the Th17 lineage, regulating genes associated with innate skin immunity along with IL-17A and IL-17F.
IL-22 induces acute phase reactants, antimicrobial proteins, and enhances keratinocyte mobility.
It is upregulated during chronic inflammation, activating intracellular kinases and transcription factors, and plays a critical role in host defense against extracellular pathogens and wound healing.
IL-22 mediates IL-23-induced acanthosis and dermal inflammation via STAT3 activation.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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