Thermo Fisher Scientific KSR2 Polyclonal Antibody, MaxPab

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KSR2 (NP_775869.2, 1 a.a. approximately 829 a.a) full-length human protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:KSR2,uniProtId:Q6VAB6-1,ncbiNodeId:9606,antigenRange:1-950,antigenLength:950,antigenImageFileName:H00283455-B01P_KSR2_Q6VAB6-1_House_mouse.svg,antigenImageFileNamePDP:H00283455-B01P_KSR2_Q6VAB6-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MTDEQVCETV EKYGANREEC ARLNASLSCL RNVHMSGGNL SKQDWTIQWP TTETGKENNP VCPPEPTPWI RTHLSQSPRV PSKCVQHYCH TSPTPGAPVY THVDRLTVDA YPGLCPPPPL ESGHRSLPPS PRQRHAVRTP PRTPNIVTTV TPPGTPPMRK KNKLKPPGTP PPSSRKLIHL IPGFTALHRS KSHEFQLGHR VDEAHTPKAK KKSKPLNLKI HSSVGSCENI PSQQRSPLLS ERSLRSFFVG HAPFLPSTPP VHTEANFSAN TLSVPRWSPQ IPRRDLGNSI KHRFSTKYWM SQTCTVCGKG MLFGLKCKNC KLKCHNKCTK EAPPCHLLII HRGDPARLVR TESVPCDINN PLRKPPRYSD LHISQTLPKT NKINKDHIPV PYQPDSSSNP SSTTSSTPSS PAPPLPPSAT PPSPLHPSPQ CTRQQKNFNL PASHYYKYKQ QFIFPDVVPV PETPTRAPQV ILHPVTSNPI LEGNPLLQIE VEPTSENEEV HDEAEESEDD FEEMNLSLLS ARSFPRKASQ TSIFLQEWDI PFEQLEIGEL IGKGRFGQVY HGRWHGEVAI RLIDIERDNE DQLKAFKREV MAYRQTRHEN VVLFMGACMS PPHLAIITSL CKGRTLYSVV RDAKIVLDVN KTRQIAQEIV KGMGYLHAKG ILHKDLKSKN VFYDNGKVVI TDFGLFSISG VLQAGRREDK LRIQNGWLCH LAPEIIRQLS PDTEEDKLPF SKHSDVFALG TIWYELHARE WPFKTQPAEA IIWQMGTGMK PNLSQIGMGK EISDILLFCW AFEQEERPTF TKLMDMLEKL PKRNRRLSHP GHFWKSAEL

Target Information

KSR2 serine/threonine kinase or kinase suppressor of Ras 2 specifically regulates the activity of MEKK3 and COT but not other members of the MAP3K family. KSR interacts with a regulatory Raf molecule in cis to induce a conformational switch of MEK, facilitating MEK`s phosphorylation by a separate catalytic Raf molecule in trans. Blocks MAP3K8 kinase activity and MAP3K8- mediated signaling. Acts as a negative regulator of MAP3K3- mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.