Thermo Fisher Scientific CCBE1 Polyclonal Antibody
Human CCBE1 단백질을 인식하는 Rabbit Polyclonal Antibody로 IHC 및 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. PBS 기반 버퍼에 40% 글리세롤 포함, 장기 보관 시 -20°C 권장. 연구용으로만 사용.
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Thermo Fisher Scientific CCBE1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | View publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CCBE1. Recombinant protein control fragment (Product #RP-98285). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2639342 |
Product Specific Information
Immunogen sequence:
CECREGYIRE DDGKTCTRGD KYPNDTGHEK SENMVKAGTC CATCKEFYQM KQTVLQLKQK IALLPNNAAD LGKYITGDKV LASNTYLPGP PG
Antigen sequence identity:
- Mouse: 89%
- Rat: 90%
Target Information
The gene encoding CCBE1 (Collagen and calcium-binding EGF domain-containing protein 1) is located on chromosome 18, a region often deleted in breast and prostate cancers.
CCBE1 is a 406 amino acid secreted protein containing two collagen-like domains and one calcium-binding EGF-like domain.
EGF-like domains typically include six cysteine residues forming disulfide bonds.
Calcium-binding EGF-like domains are sensitive to amino acid substitutions that can alter structure or calcium affinity, affecting protein function.
Downregulation of CCBE1 is frequently observed in breast cancer, suggesting that loss of CCBE1 may impact cell adhesion and mobility due to its extracellular nature.
Three isoforms are produced through alternative splicing events.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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(이미지 파일: PA5-59534_CCBE1_Q6UXH8-1_Rabbit_PDP.jpeg, PA5-59534_CCBE1_Q6UXH8-1_Rabbit.svg)
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