Thermo Fisher Scientific AP2S1 Polyclonal Antibody
Thermo Fisher Scientific의 AP2S1 Polyclonal Antibody는 인간 AP2S1 단백질을 인식하는 토끼 IgG 항체입니다. Western blot, IHC, ICC/IF 등 다양한 응용에 적합하며, 고순도 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 -20°C에서 보관합니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific AP2S1 Polyclonal Antibody
Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human AP2S1 (Accession P53680), corresponding to amino acid residues M1–V39 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852315 |
Product Specific Information
Antibody detects endogenous levels of total AP2S1.
Target Information
AP2S1 is a component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via vesicles in various membrane traffic pathways. They are vesicle coat components involved in cargo selection and vesicle formation.
AP-2 participates in clathrin-dependent endocytosis, where cargo proteins are incorporated into clathrin-coated vesicles (CCVs) destined for fusion with early endosomes. The clathrin lattice acts as a mechanical scaffold but does not directly bind membrane components.
Clathrin-associated adaptor protein (AP) complexes can bind both clathrin and the lipid/protein components of membranes, serving as major clathrin adaptors for CCV formation. AP-2 also acts as a cargo receptor to selectively sort membrane proteins involved in receptor-mediated endocytosis and plays a role in recycling synaptic vesicle membranes.
AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within cytosolic tails of transmembrane cargo molecules and may contribute to post-endocytic trafficking via the ARF6-regulated, non-clathrin pathway.
The AP-2 alpha and sigma subunits contribute to recognition of the [ED]-X-X-X-L-[LI] motif. AP-2 may also play a role in extracellular calcium homeostasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 없음)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.