Thermo Fisher Scientific PGR Monoclonal Antibody (OTI24D6), TrueMAB
인체 PGR 단백질(Progesterone Receptor)을 인식하는 단클론 항체로, Western blot 및 IHC(P) 실험에 적합합니다. 마우스 IgG2b 아이소타입이며, 고순도 액상형으로 제공됩니다. -20°C에서 안정적으로 보관 가능하며 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Assay-dependent
Immunohistochemistry (Paraffin) (IHC (P))
- Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI24D6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–298 of human PGR produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. It mediates the physiological effects of progesterone, playing a central role in reproductive events associated with the establishment and maintenance of pregnancy.
PR exists as two forms:
- Form A (94 kDa)
- Form B (120 kDa)
These forms arise from alternative translation initiation sites. PR-B is transcriptionally active and regulates genes involved in endometrial maintenance, pregnancy, and inhibition of ovulation. PR-A differs by a 165 amino acid deletion at the N-terminus, exposing a 140 amino acid inhibitory domain that represses steroid hormone transcriptional activity.
In its inactive state, PgR forms a multiprotein complex with heat shock proteins and immunophilins. Upon progesterone binding, the receptor undergoes conformational change, dimerizes, and binds to progesterone response elements (PRE), activating transcription. Null mutations in the PGR gene cause reproductive abnormalities.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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