Thermo Fisher Scientific TMEM70 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human TMEM70. Recombinant protein control fragment (Product #RP-91012). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TMEM70,uniProtId:Q9BUB7-1,ncbiNodeId:9606,antigenRange:164-260,antigenLength:260,antigenImageFileName:PA5-54717_TMEM70_Q9BUB7-1_Rabbit.svg,antigenImageFileNamePDP:PA5-54717_TMEM70_Q9BUB7-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2648722

Product Specific Information

Immunogen sequence: KGYVIRLYHE ATTDTYKAIT YNAMLAETST VFHQNDVKIP DAKHVFTTFY AKTKSLLVNP VLFPNREDYI HLMGYDKEEF ILYMEETSEE KRHKDDK

Highest antigen sequence identity to the following orthologs: Mouse - 71%, Rat - 71%.

Target Information

TMEM70 is a recently identified mitochondrial protein that is thought to play a role in the biogenesis of the ATP synthase in higher eukaryotes. Mutations in this gene result in early neonatal onset of hypotonia, hypertrophic cardiomyopathy, lactic acidos and 3-methylglutaconic aciduria (3-MGC-uria), and usually cause death within the first six weeks of life, although some patients survive much longer. Little is known of the role of TMEM70, but it is conserved across multicellular eukaryotic organisms. It contains a conserved DUF1301 domain and two putative transmembrane regions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.