Thermo Fisher Scientific DDX58 Monoclonal Antibody (OTI6C1), TrueMAB
Human RIG-I 단백질을 인식하는 Mouse monoclonal antibody로, WB, IHC(P), ICC/IF에 사용 가능. 고순도 Affinity chromatography 정제, 1 mg/mL 농도. PBS/BSA/glycerol buffer에 보관하며 -20°C에서 안정적. 연구용 전용 시약.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:4,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6C1 |
| Immunogen | Full length human recombinant protein of human DDX58 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor (PRR) involved in the recognition of viral double-stranded RNA (dsRNA). Along with MDA5, RIG-I detects viral dsRNA and activates the innate immune response. Both MDA5 and RIG-I are RNA helicases with overlapping and distinct roles.
RIG-I is activated by dsRNAs without a 5'-triphosphate end and short dsRNAs, whereas MDA5 is activated by long dsRNAs. Once activated, both proteins signal through IPS-1, activating transcription factors NF-kappaB and IRF-3, leading to apoptosis, cytokine signaling, and inflammation.
RIG-I is essential for signaling by influenza A and B, human respiratory syncytial virus, paramyxoviruses, Japanese encephalitis virus, and West Nile virus. MicroRNA-146a negatively regulates RIG-I targets (TRAF6, IRAK1, IRAK2), providing feedback inhibition of the antiviral response. RIG-I has also been implicated in cytosolic DNA detection through RNA polymerase III activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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